Blogs

The oncoprotein SET can bind to p53 and inhibits p53 transcriptional activity in unstressed cells. To identify the genes regulated by SET in a p53-dependent manner, the endogenous SET was depleted by siRNA in control or p53 knockout U2OS cells. We use BxGenomics DEG and Venn Diagram tools to find genes regulated by p53-SET. 

Reference: Nature. 2016 Oct 6;538(7623):118-122. doi: 10.1038/nature19759.

We use BxGenomics to examine RNA-Seq data from three key time points during human iPSC differentiation into mature muscle fibers with motor neurons.  We can detect consistent genes changes as the cells differentiate, and myogenesis and nurogenesis genes are highly enriched in later time points.

Reference: Cells. 2020 Jun 23;9(6):1531. doi: 10.3390/cells9061531.

BxSeqTools Enables Gene Sequence Anaysis and Molecular Cloning in The Cloud

BxSeqTools is an integrated system allowing users to perform sequence analysis online, use your own data and resources, use public databases like GenBank, organize the results, and perform further molecular cloning work using built in bioinformatics tools. Everything is seamlessly integrated and readily available online.