Knowledge resources for lab management and data analysis

RNA-Seq Case Study: Genes Regulated by p53-SET Interplay

Published by BxGenomics @ July 25, 2022, 9:18 pm

The oncoprotein SET can bind to p53 and inhibits p53 transcriptional activity in unstressed cells. To identify the genes regulated by SET in a p53-dependent manner, the endogenous SET was depleted by siRNA in control or p53 knockout U2OS cells. We use BxGenomics DEG and Venn Diagram tools to find genes regulated by p53-SET. 

Reference: Nature. 2016 Oct 6;538(7623):118-122. doi: 10.1038/nature19759.


RNA-Seq Case Study: iPSC Differentiation into Muscle and Neuron

Published by BxGenomics @ July 24, 2022, 11:12 am

We use BxGenomics to examine RNA-Seq data from three key time points during human iPSC differentiation into mature muscle fibers with motor neurons.  We can detect consistent genes changes as the cells differentiate, and myogenesis and nurogenesis genes are highly enriched in later time points.

Reference: Cells. 2020 Jun 23;9(6):1531. doi: 10.3390/cells9061531.


Ultimate Molecular Cloning Guides

Published by Ron @ July 1, 2022, 9:33 am

BxSeqTools Enables Gene Sequence Anaysis and Molecular Cloning in The Cloud

BxSeqTools is an integrated system allowing users to perform sequence analysis online, use your own data and resources, use public databases like GenBank, organize the results, and perform further molecular cloning work using built in bioinformatics tools. Everything is seamlessly integrated and readily available online.

mLIMS Release Notes in December, 2021

Published by mLIMS @ December 6, 2021, 1:27 pm
  • Improved Litter Survival  and Breeding Performance Reports
  • Improved Cage Usage Reports
  • Create Animal Tags
  • Customize the Strain Dropdown List
  • Create Forms (Premium Feature)

Learn more at