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RNA-Seq Case Study: Genes Regulated by p53-SET Interplay

Published by BxGenomics @ July 25, 2022, 9:18 pm

The oncoprotein SET can bind to p53 and inhibits p53 transcriptional activity in unstressed cells. To identify the genes regulated by SET in a p53-dependent manner, the endogenous SET was depleted by siRNA in control or p53 knockout U2OS cells. We use BxGenomics DEG and Venn Diagram tools to find genes regulated by p53-SET. 

Reference: Nature. 2016 Oct 6;538(7623):118-122. doi: 10.1038/nature19759.